Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Wnt3a  wingless-type MMTV integration site family, member 3A   (Synonyms: Wnt-3a)
Results	Reference
1	J:67399 Abu-Abed S, Dolle P, Metzger D, Beckett B, Chambon P, Petkovich M, The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures. Genes Dev. 2001 Jan 15;15(2):226-40
1*	J:81583 Abu-Abed S, Dolle P, Metzger D, Wood C, MacLean G, Chambon P, Petkovich M, Developing with lethal RA levels: genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1. Development. 2003 Apr;130(7):1449-59
1	J:232560 Anderson MJ, Schimmang T, Lewandoski M, An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension. PLoS Genet. 2016 May;12(5):e1006018
1	J:220460 Andre P, Song H, Kim W, Kispert A, Yang Y, Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development. 2015 Apr 15;142(8):1516-27
1	J:190545 Boulet AM, Capecchi MR, Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo. Dev Biol. 2012 Nov 15;371(2):235-45
1	J:236315 Chalamalasetty RB, Ajima R, Garriock RJ, Kennedy MW, Tessarollo L, Yamaguchi TP, A new gain-of-function mouse line to study the role of Wnt3a in development and disease. Genesis. 2016 Sep;54(9):497-502
1	J:106970 Chan BW, Chan KS, Koide T, Yeung SM, Leung MB, Copp AJ, Loeken MR, Shiroishi T, Shum AS, Maternal diabetes increases the risk of caudal regression caused by retinoic acid. Diabetes. 2002 Sep;51(9):2811-6
1*	J:80954 Chapman DL, Papaioannou VE, Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6. Nature. 1998 Feb 12;391(6668):695-7
1	J:67377 Chung AC, Katz D, Pereira FA, Jackson KJ, DeMayo FJ, Cooney AJ, O'Malley BW, Loss of orphan receptor germ cell nuclear factor function results in ectopic development of the tail bud and a novel posterior truncation. Mol Cell Biol. 2001 Jan;21(2):663-77
1	J:102820 Conway SJ, Bundy J, Chen J, Dickman E, Rogers R, Will BM, Decreased neural crest stem cell expansion is responsible for the conotruncal heart defects within the splotch (Sp(2H))/Pax3 mouse mutant. Cardiovasc Res. 2000 Aug;47(2):314-28
1	J:269325 De Castro SCP, Gustavsson P, Marshall AR, Gordon WM, Galea G, Nikolopoulou E, Savery D, Rolo A, Stanier P, Andersen B, Copp AJ, Greene NDE, Overexpression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice. Hum Mol Genet. 2018 Dec 15;27(24):4218-4230
1	J:294824 Dias A, Lozovska A, Wymeersch FJ, Novoa A, Binagui-Casas A, Sobral D, Martins GG, Wilson V, Mallo M, A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation. Elife. 2020 Jun 29;9:e56615
1	J:94049 Galceran J, Sustmann C, Hsu SC, Folberth S, Grosschedl R, LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes Dev. 2004 Nov 15;18(22):2718-23
1	J:31335 Greco TL, Takada S, Newhouse MM, McMahon JA, McMahon AP, Camper SA, Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev. 1996 Feb 1;10(3):313-24
1	J:334609 Hatakeyama Y, Saito N, Mii Y, Takada R, Shinozuka T, Takemoto T, Naoki H, Takada S, Intercellular exchange of Wnt ligands reduces cell population heterogeneity during embryogenesis. Nat Commun. 2023 Apr 6;14(1):1924
1	J:128377 Hatch EP, Noyes CA, Wang X, Wright TJ, Mansour SL, Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium. Development. 2007 Oct;134(20):3615-25
1	J:119561 Hirata T, Nakazawa M, Muraoka O, Nakayama R, Suda Y, Hibi M, Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions. Development. 2006 Oct;133(20):3993-4004
1*	J:79394 Ishibashi M, McMahon AP, A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo. Development. 2002 Oct;129(20):4807-19
1*	J:67969 Koizumi Ki, Nakajima M, Yuasa S, Saga Y, Sakai T, Kuriyama T, Shirasawa T, Koseki H, The role of presenilin 1 during somite segmentation. Development. 2001 Apr;128(8):1391-402
1	J:130851 Lavado A, Lagutin OV, Oliver G, Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon. Development. 2008 Feb;135(3):441-50
1	J:59283 Lee SM, Tole S, Grove E, McMahon AP, A local Wnt-3a signal is required for development of the mammalian hippocampus. Development. 2000 Feb;127(3):457-67
1*	J:165715 Lee YJ, McPherron A, Choe S, Sakai Y, Chandraratna RA, Lee SJ, Oh SP, Growth differentiation factor 11 signaling controls retinoic acid activity for axial vertebral development. Dev Biol. 2010 Nov 1;347(1):195-203
1	J:264113 Lopez-Escobar B, Caro-Vega JM, Vijayraghavan DS, Plageman TF, Sanchez-Alcazar JA, Moreno RC, Savery D, Marquez-Rivas J, Davidson LA, Ybot-Gonzalez P, The non-canonical Wnt-PCP pathway shapes the mouse caudal neural plate. Development. 2018 May 8;145(9):dev157487
1	J:154452 Martinez-Ferre A, Martinez S, The development of the thalamic motor learning area is regulated by Fgf8 expression. J Neurosci. 2009 Oct 21;29(42):13389-400
1	J:270575 Mastromina I, Verrier L, Silva JC, Storey KG, Dale JK, Myc activity is required for maintenance of the neuromesodermal progenitor signalling network and for segmentation clock gene oscillations in mouse. Development. 2018 Jul 30;145(14):dev161091
1	J:327818 Murphy P, Armit C, Hill B, Venkataraman S, Frankel P, Baldock RA, Davidson DR, Integrated analysis of Wnt signalling system component gene expression. Development. 2022 Aug 15;149(16):dev200312
1	J:60644 Nagai T, Aruga J, Minowa O, Sugimoto T, Ohno Y, Noda T, Mikoshiba K, Zic2 regulates the kinetics of neurulation. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1618-23
1*	J:14717 Parr BA, Shea MJ, Vassileva G, McMahon AP, Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development. 1993 Sep;119(1):247-61
1	J:127039 Rash BG, Grove EA, Patterning the dorsal telencephalon: a role for sonic hedgehog?. J Neurosci. 2007 Oct 24;27(43):11595-603
1	J:178496 Rash BG, Grove EA, Shh and Gli3 regulate formation of the telencephalic-diencephalic junction and suppress an isthmus-like signaling source in the forebrain. Dev Biol. 2011 Nov 15;359(2):242-50
1	J:144016 Ribes V, Le Roux I, Rhinn M, Schuhbaur B, Dolle P, Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways. Development. 2009 Feb;136(4):665-76
1	J:106551 Satoh W, Gotoh T, Tsunematsu Y, Aizawa S, Shimono A, Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development. 2006 Mar;133(6):989-99
1	J:154904 Savory JG, Bouchard N, Pierre V, Rijli FM, De Repentigny Y, Kothary R, Lohnes D, Cdx2 regulation of posterior development through non-Hox targets. Development. 2009 Dec;136(24):4099-110
1	J:56417 Shum AS, Poon LL, Tang WW, Koide T, Chan BW, Leung YC, Shiroishi T, Copp AJ, Retinoic acid induces down-regulation of Wnt-3a, apoptosis and diversion of tail bud cells to a neural fate in the mouse embryo. Mech Dev. 1999 Jun;84(1-2):17-30
1	J:186213 Sparrow DB, Chapman G, Smith AJ, Mattar MZ, Major JA, O'Reilly VC, Saga Y, Zackai EH, Dormans JP, Alman BA, McGregor L, Kageyama R, Kusumi K, Dunwoodie SL, A mechanism for gene-environment interaction in the etiology of congenital scoliosis. Cell. 2012 Apr 13;149(2):295-306
1*	J:30825 Sporle R, Gunther T, Struwe M, Schughart K, Severe defects in the formation of epaxial musculature in open brain (opb) mutant mouse embryos. Development. 1996 Jan;122(1):79-86
1	J:278240 Tahara N, Kawakami H, Chen KQ, Anderson A, Yamashita Peterson M, Gong W, Shah P, Hayashi S, Nishinakamura R, Nakagawa Y, Garry DJ, Kawakami Y, Sall4 regulates neuromesodermal progenitors and their descendants during body elongation in mouse embryos. Development. 2019 Jul 15;146(14):dev177659
1	J:16716 Takada S, Stark KL, Shea MJ, Vassileva G, McMahon JA, McMahon AP, Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev. 1994 Jan;8(2):174-89
1*	J:146657 Witte F, Dokas J, Neuendorf F, Mundlos S, Stricker S, Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation. Gene Expr Patterns. 2009 Apr;9(4):215-23
1	J:152813 Wolf M, Lommes P, Sock E, Reiprich S, Friedrich RP, Kriesch J, Stolt CC, Bermingham JR Jr, Wegner M, Replacement of related POU transcription factors leads to severe defects in mouse forebrain development. Dev Biol. 2009 Aug 15;332(2):418-28
1	J:272581 Wymeersch FJ, Skylaki S, Huang Y, Watson JA, Economou C, Marek-Johnston C, Tomlinson SR, Wilson V, Transcriptionally dynamic progenitor populations organised around a stable niche drive axial patterning. Development. 2019 Jan 2;146(1):dev168161
1	J:59271 Yamaguchi TP, Takada S, Yoshikawa Y, Wu N, McMahon AP, T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev. 1999 Dec 15;13(24):3185-90
1	J:154781 Young T, Rowland JE, van de Ven C, Bialecka M, Novoa A, Carapuco M, van Nes J, de Graaff W, Duluc I, Freund JN, Beck F, Mallo M, Deschamps J, Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Dev Cell. 2009 Oct;17(4):516-26
1	J:154982 Yun S, Saijoh Y, Hirokawa KE, Kopinke D, Murtaugh LC, Monuki ES, Levine EM, Lhx2 links the intrinsic and extrinsic factors that control optic cup formation. Development. 2009 Dec;136(23):3895-906
1	J:338206 Zeng H, Liu A, TMEM132A regulates mouse hindgut morphogenesis and caudal development. Development. 2023 Jul 15;150(14)